The Johnson & Johnson's Tylenol Controversies

            




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MAKING THE PUBLIC AWARE OF RISKS

Exhibit I

Comparative Study: Aspirin, Acetaminophen and Ibuprofen

ASPIRIN

Aspirin is widely used for relieving pain and reducing fever in adults. Aspirin also relieves mild itching and reduces swelling and inflammation. As it is effective against pain, swelling and inflammation, aspirin is often specifically recommended for treating arthritis, as well as many other conditions and injuries. However, people who have the following problems are cautioned against taking aspirin: 

?         People who get stomach irritation after taking aspirin,

?         People who are allergic to aspirin,

?         People who take blood thinners, and

?         People who have a hangover.

In addition, a person should not take aspirin if he or she has ulcers or gout. Also, people with asthma or hearing loss may have problems taking aspirin. Children and teenagers should not take aspirin as its use in these age groups is associated with a rare and serious brain and liver disorder called Reye’s syndrome.

ACETAMINOPHEN

Acetaminophen relieves mild pain and reduces fever as effectively as aspirin, but does not reduce inflammation, making it ineffective for treating arthritis. However, acetaminophen can be used by people who can’t take aspirin because of aspirin-related allergic reactions, stomach irritation or ringing in the ears. In addition, acetaminophen is safe for infants, children and teens. Common brands of acetaminophen include Tylenol and Panadol.

While acetaminophen is recommended over aspirin for some people, it does have some side effects. High doses or regular, long-term use can cause liver damage, especially if used with alcohol. Acetaminophen should not be used on a regular basis by people who suffer from anemia or liver or kidney diseases. In addition, it should not be used without a doctor’s recommendation to treat:

?         A fever over 103.1 degrees for more than three days, or

?         Recurring fever.

IBUPROFEN

Ibuprofen is effective for relief of pain, fever and inflammation, and for many people, is an effective alternative to aspirin for the treatment of arthritis. It is also less irritating to the stomach than aspirin and does not cause ringing in the ears. It does not cause severe liver problems like acetaminophen. There is less information on the effects of ibuprofen on children and so many docts still consider acetaminophen as the safest drug for children and teenagers. Ibuprofen is not safe for use if a person has:

?         Asthma and nasal polyps

?         A stomach or intestinal disorder

?         A skin condition called angioedema

?         An allergic reaction to other anti-inflammatory medications, including aspirin,

?         Liver or kidney disease,

?         A blood clotting disorder, or

?         Heart failure.

Source: www.yourhealth.com

 

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